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Background
Epidemiology and management practices of invasive fungal diseases (IFD) after allogeneic haematopoietic stem cell transplantation (HSCT) are a subject of constant change. We investigated the contemporary incidence, diagnostics, antifungal management and outcome at a major paediatric transplant centre in Germany.
Methods
The single‐centre retrospective observational study included all...
Background
Posaconazole (PCZ) is a triazole approved for prophylaxis of invasive fungal infections.
Objectives
Herein, the impact of clinical variables on PCZ plasma concentrations (PPCs) attained with PCZ delayed‐release tablet (DRT) was investigated and compared with a historical cohort treated with PCZ oral suspension (OS).
Patients/Methods
Steady‐state PCZ PPCs in 513 patients with haematologic...
Background
Onychomycosis affects almost 6% of the world population. Topical azoles and systemic antifungal agents are of low efficacy and can have undesirable side effects. An effective, non‐invasive therapy for onychomycosis is an unmet clinical need.
Objective
Determine the efficacy threshold of non‐thermal atmospheric plasma (NTAP) to treat onychomycosis in an in vitro model.
Methods
A novel...
Background
Oral follow‐up therapy is problematic in moulds with reduced azole‐susceptibility, such as azole‐resistant Aspergillus fumigatus infection. Currently, only intravenous liposomal amphotericin B (L‐AmB) is advocated by guidelines for the treatment of azole‐resistant aspergillosis infections. Preclinical research indicates that high‐dose posaconazole (HD‐POS) might be a feasible option provided...
Background
Fungal infections are highly prevalent and are responsible for high rates of morbidity and mortality. In this context, the search for new treatment alternatives is very relevant.
Objectives
Analyse chemical compounds for antifungal potential against dermatomycosis fungi.
Methods
The antifungal activity of 121 compounds, intermediates or derivatives of 1,3‐bis(aryloxy)propane substituted...
Background
Progressive disseminated histoplasmosis (PDH) is an important cause of mortality in persons living with HIV (PLHIV), especially in countries where patients have limited access to antiretroviral therapies and diagnostic testing.
Objective
A lateral flow assay (LFA) to detect Histoplasma capsulatum antigen in serum developed by MiraVista® was evaluated.
Methods
We tested 75 serum samples:...
Background
Lanoconazole (LCZ) is a topical antifungal agent clinically used to treat fungal infections such as tinea pedis. LCZ has not only antifungal effects but also anti‐inflammatory effects, which have the potential to provide additional clinical benefits. However, the characteristic features of the inhibitory effects of LCZ on skin inflammation remain unclear.
Objective
We evaluated the inhibitory...
Background
Invasive fungal diseases (IFD) are associated with significant treatment‐related costs in patients with haematological malignancies (HM).
Objectives
The objectives of this study were to characterise the gross and attributable hospitalisation costs of a variety of IFD in patients with HM by linking state‐wide hospital administrative and costing datasets.
Patients/Methods
We linked the...
Cryptococcal meningitis is a several disease common in late stage of HIV infection. Detection of cryptococcal antigen (CrAg) is an important for early diagnosis of this invasive mycosis. The pre‐emptive treatment for isolated antigenemia prevents the onset of meningoencephalitis. Screening CrAg in patients with low CD4 count is cost‐effective in countries with prevalence of antigenemia above 3%. However,...
Background
The infections caused by fungi represent a global concern and an important cause of hospital admissions in endemic areas. The influence of socio‐environmental factors in infectious diseases has been documented; however, this phenomenon remains unclear regarding mycoses.
Objectives
This study aimed to analyse the spatio‐temporal dynamics of hospitalisations for mycoses (HM) and the association...
Objective
To assess the diagnostic value of serum Candida mannan antigen (MN) and anti‐mannan IgG and IgM antibodies for candidiasis.
Methods
This study was a prospective cohort study. Clinical data and venous blood samples from 23 medical centres in Beijing, China were collected between 1 January 2017 and 31 December 2018. All collected specimens were tested within one week for serum Candida MN...
Background
Onychomycosis is a fungal infection of the nails and is one of the most common dermatological infections worldwide. Infection occurs predominantly in the nails of the feet and if left untreated patients, particularly in at‐risk populations, can develop more serious complications, including pain, fissuring and secondary infections. Fungal infections are also contagious and may spread to...
Background
Cutaneous phaeohyphomycosis is an emerging disease in immunocompromised patients, being Alternaria one of the most common genera reported as a causative agent. Species identification is not carried out mainly due to the complexity of the genus. Analysis of the ITS barcode has become standard for fungal identification, but in Alternaria it is only able to discriminate among species‐groups...
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